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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1929 1
1931 1
1962 1
1968 1
1969 1
1972 1
1973 1
1975 2
1976 1
1977 7
1978 5
1979 12
1980 5
1981 7
1982 7
1983 6
1984 9
1985 13
1986 15
1987 14
1988 13
1989 14
1990 14
1991 21
1992 25
1993 20
1994 28
1995 31
1996 34
1997 46
1998 39
1999 46
2000 46
2001 62
2002 68
2003 80
2004 86
2005 77
2006 94
2007 111
2008 111
2009 112
2010 139
2011 163
2012 165
2013 187
2014 233
2015 251
2016 284
2017 280
2018 349
2019 336
2020 415
2021 457
2022 474
2023 488
2024 277

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5,228 results

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Page 1
Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion.
Matsuda T, Irie T, Katsurabayashi S, Hayashi Y, Nagai T, Hamazaki N, Adefuin AMD, Miura F, Ito T, Kimura H, Shirahige K, Takeda T, Iwasaki K, Imamura T, Nakashima K. Matsuda T, et al. Neuron. 2019 Feb 6;101(3):472-485.e7. doi: 10.1016/j.neuron.2018.12.010. Epub 2019 Jan 9. Neuron. 2019. PMID: 30638745 Free article.
However, epigenetic remodeling during neuronal reprogramming has not been well reconciled with transcriptional regulation. Here we show that NeuroD1 achieves direct neuronal conversion from mouse microglia both in vitro and in vivo. ...In parallel, the microglial epigeneti …
However, epigenetic remodeling during neuronal reprogramming has not been well reconciled with transcriptional regulation. Here we sh …
Efficacy, safety and cardiovascular outcomes of once-daily oral semaglutide in patients with type 2 diabetes: The PIONEER programme.
Thethi TK, Pratley R, Meier JJ. Thethi TK, et al. Diabetes Obes Metab. 2020 Aug;22(8):1263-1277. doi: 10.1111/dom.14054. Epub 2020 May 13. Diabetes Obes Metab. 2020. PMID: 32267058 Free PMC article. Review.
Oral semaglutide, the first oral GLP-1RA, has recently been approved for clinical use, based on the results of the randomized, Phase 3a Peptide InnOvatioN for Early diabEtes tReatment (PIONEER) clinical trials. The PIONEER programme tested oral semaglutide in patien …
Oral semaglutide, the first oral GLP-1RA, has recently been approved for clinical use, based on the results of the randomized, Phase 3a Pept …
Pioneer factors in viral infection.
Neugebauer E, Bastidas-Quintero AM, Weidl D, Full F. Neugebauer E, et al. Front Immunol. 2023 Oct 9;14:1286617. doi: 10.3389/fimmu.2023.1286617. eCollection 2023. Front Immunol. 2023. PMID: 37876935 Free PMC article. Review.
Some pioneer factors are actively induced or downregulated by viral infection. ...In this article, we review the current state of research on how different viruses (Herpesviruses, Papillomaviruses and Hepatitis B virus) use pioneer factors for their viral replicatio …
Some pioneer factors are actively induced or downregulated by viral infection. ...In this article, we review the current state of res …
Editorial.
Robinson PG. Robinson PG. Community Dent Health. 2017 Mar;34(1):3. doi: 10.1922/cdh_lennon010.1922/cdhrobinson01. Community Dent Health. 2017. PMID: 28561549 Free article.
He was one of a succession of icons of Dental Public Health to have filled this role including Denis O'Mullane, Martin Downer and until December, my colleague and friend Mike Lennon. Many of us have looked up to those pioneers with respect and reverence. The journal has al …
He was one of a succession of icons of Dental Public Health to have filled this role including Denis O'Mullane, Martin Downer and until Dece …
The perils of not knowing the history of the nurse practitioner role.
Berg JA. Berg JA. J Am Assoc Nurse Pract. 2020 Sep;32(9):602-609. doi: 10.1097/JXX.0000000000000441. J Am Assoc Nurse Pract. 2020. PMID: 32890036
Historians tell us there are perils to not knowing history and that studying history allows us to understand our past as well as our present. The how and why of our nurse practitioner (NP) role today lies in our history. ...These pioneer NP participants highlighted …
Historians tell us there are perils to not knowing history and that studying history allows us to understand our past as well as our …
Thyroidectomy.
Biello A, Kinberg EC, Wirtz ED. Biello A, et al. 2022 Nov 14. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2022 Nov 14. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 33085426 Free Books & Documents.
Thyroidectomy is a well-described procedure used to excise the thyroid gland. It is a common procedure in modern medicine and may be used to treat malignancy, benign disease, or hormonal disease that is not responsive to medical management. ...Thyroidectomy, as a procedure …
Thyroidectomy is a well-described procedure used to excise the thyroid gland. It is a common procedure in modern medicine and may be …
Cell fate control by pioneer transcription factors.
Iwafuchi-Doi M, Zaret KS. Iwafuchi-Doi M, et al. Development. 2016 Jun 1;143(11):1833-7. doi: 10.1242/dev.133900. Development. 2016. PMID: 27246709 Free PMC article. Review.
Here, we provide an overview of the contexts in which pioneer factors function, how they can target silent genes, and their limitations at regions of heterochromatin. Understanding how pioneer factors regulate gene expression greatly enhances our understanding of ho …
Here, we provide an overview of the contexts in which pioneer factors function, how they can target silent genes, and their limitatio …
PBX1 as Pioneer Factor: A Case Still Open.
Grebbin BM, Schulte D. Grebbin BM, et al. Front Cell Dev Biol. 2017 Feb 14;5:9. doi: 10.3389/fcell.2017.00009. eCollection 2017. Front Cell Dev Biol. 2017. PMID: 28261581 Free PMC article. Review.
Pioneer factors are therefore particularly well-suited to initiate cell fate changes. To date, only a small number of pioneer factors have been identified and studied in depth, such as FOXD3/FOXA1, OCT4, or SOX2. ...
Pioneer factors are therefore particularly well-suited to initiate cell fate changes. To date, only a small number of pione …
MECHANISMS IN ENDOCRINOLOGY: Pioneer transcription factors in pituitary development and tumorigenesis.
Harris J, Gouhier A, Drouin J. Harris J, et al. Eur J Endocrinol. 2021 Jan;184(1):R1-R15. doi: 10.1530/EJE-20-0866. Eur J Endocrinol. 2021. PMID: 33112269 Review.
This action is typically exerted at enhancer regulatory sequences, thus allowing activation of new gene subsets. During pituitary development, the only pioneer with a well-documented role is Pax7 that specifies the intermediate lobe melanotrope cell fate. ...Overexp …
This action is typically exerted at enhancer regulatory sequences, thus allowing activation of new gene subsets. During pituitary developmen …
Epigenetic pioneering by SWI/SNF family remodelers.
Ahmad K, Brahma S, Henikoff S. Ahmad K, et al. Mol Cell. 2024 Jan 18;84(2):194-201. doi: 10.1016/j.molcel.2023.10.045. Epub 2023 Nov 27. Mol Cell. 2024. PMID: 38016477 Free article. Review.
Recent structural studies have revealed multiple modes of TF engagement with nucleosomes, but how initial "pioneering" results in steady-state DNA accessibility for further TF binding and RNA polymerase II (RNAPII) engagement has been unclear. Even less well underst …
Recent structural studies have revealed multiple modes of TF engagement with nucleosomes, but how initial "pioneering" results in ste …
5,228 results